Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
(+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
(+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
(+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
(+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | - |
Homo sapiens | |
(+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | - |
Rattus norvegicus | |
(-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
(-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
(-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
(-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
(-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | - |
Homo sapiens | |
(-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | - |
Rattus norvegicus | |
1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol | - |
Homo sapiens | |
1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol | - |
Rattus norvegicus | |
1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Homo sapiens | |
1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | - |
Rattus norvegicus | |
4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide | - |
Homo sapiens | |
4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide | - |
Rattus norvegicus | |
4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide | - |
Homo sapiens | |
4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide | - |
Rattus norvegicus | |
abiraterone acetate | - |
Homo sapiens | |
abiraterone acetate | - |
Rattus norvegicus | |
N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea | - |
Homo sapiens | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea | - |
Rattus norvegicus | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide | - |
Homo sapiens | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide | - |
Rattus norvegicus | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide | - |
Homo sapiens | |
N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide | - |
Rattus norvegicus | |
N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | - |
Homo sapiens | |
N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | - |
Rattus norvegicus | |
YM-116 | - |
Homo sapiens | |
YM-116 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-hydroxyprogesterone + AH2 + O2 | - |
Homo sapiens | ? | - |
? | |
17alpha-hydroxyprogesterone + AH2 + O2 | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17,20-lyase | - |
Homo sapiens |
17,20-lyase | - |
Rattus norvegicus |
CYP17A1 | - |
Homo sapiens |
CYP17A1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Homo sapiens | |
cytochrome b5 | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000083 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.00001 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol | |
0.000014 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000015 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000017 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000018 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-[1,1'-biphenyl]-3-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000019 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000019 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000019 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000021 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea | |
0.000022 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000024 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000024 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide | |
0.000024 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]-N'-methylurea | |
0.000025 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000026 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (-)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000026 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | |
0.000027 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000028 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-(4'-fluoro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000028 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000029 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-(4'-chloro[1,1'-biphenyl]-4-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000033 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000033 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-[1,1'-biphenyl]-4-yl-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000033 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | (-)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | |
0.000036 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | |
0.000038 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide | |
0.00004 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000044 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide | |
0.000045 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000049 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-(4'-chloro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol | |
0.000049 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide | |
0.000053 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | |
0.000054 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol | |
0.000062 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)ethyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000071 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide | |
0.000077 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000081 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[4'-[cyclopropyl(hydroxy)-1H-imidazol-4-ylmethyl][1,1'-biphenyl]-3-yl]acetamide | |
0.000092 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide | |
0.00012 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-(1H-imidazol-4-yl)-1-(4'-methoxy[1,1'-biphenyl]-4-yl)-2-methyl-1-propanol | |
0.00012 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-4-yl]acetamide | |
0.00013 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol | |
0.00015 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol | |
0.00016 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-sulfonamide | |
0.00021 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | 1-(1H-imidazol-4-yl)-2-methyl-1-[4-(2-pyridinyl)phenyl]-1-propanol | |
0.00024 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | |
0.00032 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | N-[4'-[1-hydroxy(1H-imidazol-4-yl)methyl][1,1'-biphenyl]-3-yl]acetamide | |
0.00034 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | |
0.00045 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)propyl][1,1'-biphenyl]-3-yl]acetamide | |
0.00077 | - |
in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | (+)-N-[4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl][1,1'-biphenyl]-3-yl]acetamide | |
0.001 | - |
IC50 above 0.001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C | Rattus norvegicus | (+)-N-[6-(4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl)-2-pyridyl]acetamide |