Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-iodobenzyl)-1H-imidazole | - |
Rattus norvegicus | |
1-benzyl-1H-imidazole | - |
Rattus norvegicus | |
1-[4-(4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl)piperazin-1-yl]ethanone | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenol | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenyl 4-butylbenzenesulfonate | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenyl 4-ethylbenzenesulfonate | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenyl 4-pentylbenzenesulfonate | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenyl 4-propylbenzenesulfonate | - |
Rattus norvegicus | |
4-(1H-imidazol-1-ylmethyl)phenyl biphenyl-4-sulfonate | - |
Rattus norvegicus | |
4-hydroxybenzyl imidazole | - |
Rattus norvegicus | |
4-iodobenzyl imidazole | - |
Rattus norvegicus | |
abiraterone acetate | - |
Rattus norvegicus | |
benzyl imidazole | - |
Rattus norvegicus | |
ketoconazole | - |
Rattus norvegicus | |
additional information | synthesis and inhibitory activity of a range of 4-substituted phenylsulfonate derivatives of 4-hydroxybenzyl imidazole against the two components of 17alpha-hydroxylase/17,20-lyase, namely, 17alpha-hydroxylase and 17,20-lyase, overview | Rattus norvegicus | |
toluene-4-sulfonic acid 4-imidazol-1-ylmethyl-phenyl ester | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
progesterone + AH2 + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | both hydroxylation and C-C-bond cleavage steps require NADPH and oxygen | Rattus norvegicus | ? | - |
? | |
progesterone + AH2 + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase/17,20-lyase | - |
Rattus norvegicus |
P45017alpha | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | required | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl biphenyl-4-sulfonate | |
0.00001 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl biphenyl-4-sulfonate | |
0.000014 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate | |
0.000014 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate | |
0.00002 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-ethylbenzenesulfonate | |
0.00002 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-ethylbenzenesulfonate | |
0.00003 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | toluene-4-sulfonic acid 4-imidazol-1-ylmethyl-phenyl ester | |
0.00003 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-propylbenzenesulfonate | |
0.00003 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | toluene-4-sulfonic acid 4-imidazol-1-ylmethyl-phenyl ester | |
0.00003 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-propylbenzenesulfonate | |
0.000034 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate | |
0.000034 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate | |
0.00004 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-butylbenzenesulfonate | |
0.00004 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | toluene-4-sulfonic acid 4-imidazol-1-ylmethyl-phenyl ester | |
0.00004 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | toluene-4-sulfonic acid 4-imidazol-1-ylmethyl-phenyl ester | |
0.00004 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-butylbenzenesulfonate | |
0.00007 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-butylbenzenesulfonate | |
0.00007 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-butylbenzenesulfonate | |
0.0001 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl biphenyl-4-sulfonate | |
0.0001 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl biphenyl-4-sulfonate | |
0.00011 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-ethylbenzenesulfonate | |
0.00011 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-ethylbenzenesulfonate | |
0.00013 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-pentylbenzenesulfonate | |
0.00013 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-pentylbenzenesulfonate | |
0.00016 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-pentylbenzenesulfonate | |
0.00016 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-pentylbenzenesulfonate | |
0.000164 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-iodobenzyl imidazole | |
0.000164 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-(4-iodobenzyl)-1H-imidazole | |
0.0002 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate | |
0.0002 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate | |
0.000206 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | ketoconazole | |
0.000206 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-[4-(4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl)piperazin-1-yl]ethanone | |
0.00073 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-iodobenzyl imidazole | |
0.00104 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate | |
0.00104 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate | |
0.00121 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-propylbenzenesulfonate | |
0.00121 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenyl 4-propylbenzenesulfonate | |
0.00147 | - |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-hydroxybenzyl imidazole | |
0.00147 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenol | |
0.002496 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | 4-hydroxybenzyl imidazole | |
0.0025 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 4-(1H-imidazol-1-ylmethyl)phenol | |
0.00266 | - |
IC50 against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | ketoconazole | |
0.00266 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-[4-(4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl)piperazin-1-yl]ethanone | |
0.003 | - |
IC50 above 0.003 mM against 17,20-lyase activity, pH and temperature not specified in the publication | Rattus norvegicus | benzyl imidazole | |
0.003 | - |
IC50 above 0.003 mM against 17alpha-hydroxylase activity, pH and temperature not specified in the publication | Rattus norvegicus | benzyl imidazole | |
0.003 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-benzyl-1H-imidazole | |
0.003 | - |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-benzyl-1H-imidazole | |
0.0076 | - |
inhibition of 17,20-lyase activity, pH not specified in the publication, temperature not specified in the publication | Rattus norvegicus | 1-(4-iodobenzyl)-1H-imidazole |