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Literature summary for 1.14.14.19 extracted from

  • Ogishima, T.; Mitani, F.; Suematsu, M.
    Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis (2008), J. Steroid Biochem. Mol. Biol., 111, 80-86.
    View publication on PubMed
Search for more literature for 1.14.14.19

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition with anti-P-450 reductase or limitation of NADPH preferentially reduce the lyase activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin ?
-
 ?
progesterone + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially from pancreatic cell microsomes Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
Langerhans cell
-
 Rattus norvegicus
-
additional information immunohistochemic enzyme localization analysis, overview Rattus norvegicus
-
pancreas islets of Langerhans Rattus norvegicus
-
pancreatic beta cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin Rattus norvegicus ?
-
 ?
progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome P-45017alpha
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Rattus norvegicus

General Information

General Information Comment Organism
metabolism Cyp17 is important in the metabolism of androgens, overview Rattus norvegicus