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Literature summary for 1.14.14.19 extracted from

  • Pinto-Bazurco Mendieta, M.A.; Negri, M.; Jagusch, C.; Mueller-Vieira, U.; Lauterbach, T.; Hartmann, R.W.
    Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer (2008), J. Med. Chem., 51, 5009-5018.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP17, coexpression in Escherichia coli with human NADPH-P450 reductase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-fluoro-4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)phenol hydrobromide
-
Homo sapiens
2-fluoro-4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)phenol hydrobromide
-
Homo sapiens
3-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride
-
Homo sapiens
3-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride
-
Homo sapiens
4-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride
-
Homo sapiens
4-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride
-
Homo sapiens
4-(5-(4-methoxyphenyl)-3H-inden-1-yl)pyridine hydrochloride
-
Homo sapiens
4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)benzene-1,2-diol hydrobromide
-
Homo sapiens
4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)benzene-1,2-diol hydrobromide
-
Homo sapiens
4-(6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride
-
Homo sapiens
4-(6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride
-
Homo sapiens
4-(6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride
-
Homo sapiens
4-(6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride
-
Homo sapiens
5-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol
-
Homo sapiens
5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol
-
Homo sapiens
5-(4-fluorophenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol
-
Homo sapiens
5-(4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol
-
Homo sapiens
6-(3,4-difluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
Homo sapiens
6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
Homo sapiens
6-(4-fluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
-
Homo sapiens
abiraterone
-
Homo sapiens
ketoconazole
-
Homo sapiens
additional information inhibition design, synthesis, and molecular modelling, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
CYP17
-
Homo sapiens
cytochrome P450 17alpha-hydroxylase-17,20-lyase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000064
-
-
Homo sapiens 2-fluoro-4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)phenol hydrobromide
0.000072
-
-
Homo sapiens abiraterone
0.000144
-
-
Homo sapiens 4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)benzene-1,2-diol hydrobromide
0.000163
-
-
Homo sapiens 4-(6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride
0.000188
-
-
Homo sapiens 2-fluoro-4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)phenol hydrobromide
0.000233
-
-
Homo sapiens 4-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride
0.000307
-
-
Homo sapiens 4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)benzene-1,2-diol hydrobromide
0.000333
-
-
Homo sapiens 5-(4-fluorophenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol
0.000423
-
-
Homo sapiens 6-(3,4-difluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
0.000587
-
-
Homo sapiens 6-(4-fluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
0.00122
-
-
Homo sapiens 4-(6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride
0.00235
-
-
Homo sapiens 3-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride
0.00378
-
-
Homo sapiens ketoconazole
0.005
-
above Homo sapiens 6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
0.005
-
above Homo sapiens 4-(5-(4-methoxyphenyl)-3H-inden-1-yl)pyridine hydrochloride
0.005
-
above Homo sapiens 4-(6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride
0.005
-
above Homo sapiens 4-(6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride
0.01
-
above Homo sapiens 5-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol
0.02
-
above Homo sapiens 5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol
0.02
-
above Homo sapiens 5-(4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol
0.02
-
above Homo sapiens 4-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride
0.02
-
above Homo sapiens 3-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride