Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.19 extracted from

  • Bruno, R.D.; Gover, T.D.; Burger, A.M.; Brodie, A.M.; Njar, V.C.
    17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response (2008), Mol. Cancer Ther., 7, 2828-2836.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.19

Application

Application Comment Organism
drug development the enzyme is a target for drug development in treatment of prostate cancer, in which androgens play a pivotal role, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ketoconazole unspecific inhibitor Homo sapiens
VN/124-1 a 17alpha-hydroxylase/17,20 lyase inhibitor, is cytotoxic in prostate cancer cells and synergistically induces endoplasmic reticulum stress, mechanism, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
17alpha-hydroxylase/17,20 lyase
-
 Homo sapiens
CYP17
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme catalyzes two sequential and necessary reactions in the production of androgens Homo sapiens