Literature summary for 1.14.14.19 extracted from

Souter, I.; Munir, I.; Mallick, P.; Weitsman, S.R.; Geller, D.H.; Magoffin, D.A.
Mutagenesis of putative serine-threonine phosphorylation sites proximal to Arg255 of human cytochrome P450c17 does not selectively promote its 17,20-lyase activity (2006), Fertil. Steril., 85 Suppl 1, 1290-1299.

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Protein Variants

Protein Variants	Comment	Organism
additional information	FLAG-tagged enzyme shows catalytic parameters undistinguishable from wild-type	Homo sapiens
S258A	significant decrease in both 17alpha-hydroxylase and 17,20-lyase activity	Homo sapiens
S258D	significant decrease in both 17alpha-hydroxylase and 17,20-lyase activity	Homo sapiens
T260D	significant decrease in both 17alpha-hydroxylase and 17,20-lyase activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzyme	-

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Release 2023.1 (January 2023)