Literature summary for 1.14.14.19 extracted from

Liu, Y.; Yao, Z.X.; Papadopoulos, V.
Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells (2005), Mol. Endocrinol., 19, 1918-1931.

Search for more literature for 1.14.14.19

Protein Variants

Protein Variants	Comment	Organism
additional information	17alphahydroxylase/17,20-lyase knock-down clone shows dramatically reducued human chorionic gonadotropin-induced progesterone formation and de novo synthesis of steroids. Addition of squalene epoxide, lanosterol, zymosterol, and desmosterol can rescue the hormone-induced progesterone formation	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	in addition to 17alphahydroxylase/17,20-lyase activity, enzyme can also act as squalene epoxidase	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MA-10 cell	mouse tumor leydig cell defective in 17alphahydroxylase/17,20-lyase activity	Mus musculus	-

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Release 2023.1 (January 2023)