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Literature summary for 1.14.14.19 extracted from
- 5alpha-reduced C21 steroids are substrates for human cytochrome P450c17 (2003), Arch. Biochem. Biophys., 418, 151-160.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
5alpha-pregnan-3alpha-ol-20-one | pH 7.4 | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
recombinant enzyme, expression in Saccharomyces cerevisiae, enzyme catalyzes both 17alpha-hydroxylation and 17,20-lyase reaction which eliminates at C20,21 acetate to yield a C19 steroid | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5alpha-pregnan-3,20-dione + NADPH + O2 | - |
Homo sapiens | 5alpha-pregnan-17alpha-ol-3,20-dione + NADP+ + H2O | - |
? | |
| 5alpha-pregnan-3alpha-ol-20-one + NADPH + O2 | - |
Homo sapiens | 5alpha-pregnan-3alpha,17alpha-diol-20-one + ? | - |
? | |
| additional information | enzyme also catalyzes 17,20-lyase reaction, EC4.1.2.30 | Homo sapiens | ? | - |
? | |
| pregnenolone + AH2 + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
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