Literature summary for 1.14.14.18 extracted from

Hettiarachchi, N.; Dallas, M.; Al-Owais, M.; Griffiths, H.; Hooper, N.; Scragg, J.; Boyle, J.; Peers, C.
Heme oxygenase-1 protects against Alzheimers amyloid-beta(1-42)-induced toxicity via carbon monoxide production (2014), Cell Death Dis., 5, e1569 .

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Application

Application	Comment	Organism
medicine	Hmox1 protects against amyloid beta toxicity via production of CO. Protection does not arise from inhibition of apoptosis-associated K+ efflux, but rather by inhibition of AMP-dependent protein kinase activation	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in SH-SY5Y cells	Homo sapiens
expression in SH-SY5Y cells	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09601	isoform Hmox1	-
Rattus norvegicus	P06762	-	-

Synonyms

Synonyms	Comment	Organism
Hmox1	-	Homo sapiens
Hmox1	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	pharmacological induction of Hmox1 significantly ameliorates the effects of amyloid-beta1-42 in rat primary hippocampal neurons	Rattus norvegicus
physiological function	pharmacological induction or genetic overexpression of Hmox1 significantly ameliorates the effects of amyloid-beta1-42 in SH-SY5Y cells	Homo sapiens

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Release 2023.1 (January 2023)