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Literature summary for 1.14.14.18 extracted from
- Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP (2014), Bioorg. Med. Chem. Lett., 24, 4845-4849.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoheme + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HCT-116 cell | - |
Homo sapiens | - |
| HT-29 cell | - |
Homo sapiens | - |
| MRC-5 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoheme + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heme oxygenase-1 | - |
Homo sapiens |
| HO-1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enzyme overexpression is critical for tumor cell death with an impaired mitochondrial energetics | Homo sapiens |
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Release 2023.1 (January 2023)
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