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Literature summary for 1.14.14.18 extracted from

  • Nakao, A.; Kaczorowski, D.J.; Sugimoto, R.; Billiar, T.R.; McCurry, K.R.
    Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury (2008), J. Clin. Biochem. Nutr., 42, 78-88.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
zinc protoporphyrin
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Mus musculus
Fe2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + electron donor + O2
-
Mus musculus biliverdin + Fe2+ + CO + oxidized electron donor + H2O
-
?
heme + electron donor + O2
-
Homo sapiens biliverdin + Fe2+ + CO + oxidized electron donor + H2O
-
?
heme + electron donor + O2
-
Rattus norvegicus biliverdin + Fe2+ + CO + oxidized electron donor + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
heme oxygenase-1
-
Homo sapiens
heme oxygenase-1
-
Rattus norvegicus
HO-1
-
Mus musculus
HO-1
-
Homo sapiens
HO-1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus
heme
-
Homo sapiens
heme
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus pretreatment with hemoglobin induces HO-1 and significantly reduces systemic inflammations associated with plasma concentrations of TNFalpha levels due to intestinal ischemia/reperfusion injury up

General Information

General Information Comment Organism
physiological function human patient wiht HO-1-deficiency died in his childhood with clinical manifestations, including growth failure, anemia, tissue iron deposition, lymphoadenopathy, leukocytosis and increased sensitivity to oxidative injury. HO-1 serves to provide cytoprotection against oxidative stress and is necessary in mammals Homo sapiens
physiological function inducible form of HO-1, biliverdin, and CO possess generalized endogenous anti-inflammatory activities and provide protection against intestinal ischemia/reperfusion injury. Exogenous HO-1 expression, as well as exogenously administered CO and biliverdin, have potent cytoprotective effects on intestinal ischemia/reperfusion injury as well Rattus norvegicus
physiological function mice lacking the HO-1 gene frequently die in utero, and the mice that survive to adulthood exhibit growth failure, anemia, chronic inflammation characterized by hepatosplenomegaly, leukocytosis, glomerulonephritis, and histological hepatoportal cellular infiltration. HO-1 serves to provide cytoprotection against oxidative stress and is necessary in mammals Mus musculus