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Literature summary for 1.14.14.18 extracted from

  • Zheng, J.; Tian, Q.; Hou, W.; Watts, J.A.; Schrum, L.W.; Bonkovsky, H.L.
    Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol (2008), FEBS Lett., 582, 1829-1834.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information no significant changes in HO-1 mRNA levels between ethanol treated and pair-fed control Rattus norvegicus

Application

Application Comment Organism
medicine chronic ethanol feeding induces 5-aminolevulinic acid synthase-1 (ALAS1) mRNA, cytosolic ALAS1 and mature ALAS1 protein levels, but not those of HO-1 in rat livers, which provides novel insights into the effects of chronic ethanol consumption on hepatic heme biosynthesis and porphyrias Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male sprague-dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
forebrain HO-1 mRNA levels are 66% of those in liver Rattus norvegicus
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liver
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 Rattus norvegicus
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additional information expression of HO-1 is tissue-specific, and there is a correspondence between levels of HO-1 mRNA and protein Rattus norvegicus
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skeletal muscle is slightly detectable in the abdominal skeletal muscle Rattus norvegicus
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spleen highest expression of HO-1 mRNA levels in the spleen, 6.6fold of those in the liver Rattus norvegicus
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Synonyms

Synonyms Comment Organism
heme oxygenase-1
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 Rattus norvegicus
HO-1
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 Rattus norvegicus