Cloned (Comment) | Organism |
---|---|
293FT cells transiently cotransfected with a vector containing the viral packaging proteins gag and pol, a vector containing env and pMSCV-scrttaM2puro or pRevTRE-hHO1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BeWo cell | high HO-1 expression | Homo sapiens | - |
cytotrophoblast | in vivo, high HO-1 expression. HO-1 protein is strongly expressed in proliferative, Ki67-positive cytotrophoblasts of cell columns. HO-1 is strongly expressed in cycling cytotrophoblasts of first trimester explant cultures | Homo sapiens | - |
HTR-8/SVneo cell | - |
Homo sapiens | - |
HTR-8/SVneo cell | low HO-1 expression | Homo sapiens | - |
additional information | in vivo, no HO-1 expression in extravillous trophoblasts and in nonproliferating, Kip2/p57-positive extravillous trophoblasts | Homo sapiens | - |
trophoblast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HO-1 expression is reduced upon differentiation of cytotrophoblasts into extravillous trophoblasts. Knock down of endogenous HO-1 in BeWo cells using retroviral transduction with a miRNA adapted retroviral vector targeting human HO-1 sequence | down |
Homo sapiens | HO-1 protein expression is strongly induced 24 h after DOX addition in the HTR-8/SVneo cell line | up |
General Information | Comment | Organism |
---|---|---|
physiological function | HO-1 is a negative regulator of trophoblast motility acting via up-regulation of peroxisome proliferator activated receptor (PPAR) gamma. In wound healing assays, trophoblast migration into the denuded area is diminished upon induction of HO-1 | Homo sapiens |