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Literature summary for 1.14.14.18 extracted from

  • Hartung, R.; Parapuram, S.K.; Ganti, R.; Hunt, D.M.; Chalam, K.V.; Hunt, R.C.
    Vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells (2007), Mol. Vis., 13, 66-78.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells. Activator protein-1 binding sites are located in the promoter region of HO-1, and TGF-beta also induces the enzyme, while inhibitors of TGF-beta signaling, e.g. SB431542 or TGF-beta-neutralizing antibodies, decrease the vitreous induction of HO-1, but PD98059, an inhibitor of the ERK pathway, has no effect on HO-1 induction, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens HO-1 transcriptional regulation system, overview biliverdin + Fe2+ + CO + A + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
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-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Homo sapiens
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retina
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 Homo sapiens
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retinal pigment epithelial cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?
heme + AH2 + O2 HO-1 transcriptional regulation system, overview Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
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 Homo sapiens
HO-1
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 Homo sapiens