Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | dehydrocostus lactone induces HO-1 expression in Hep-G2 cells, while mokko lactone, a reduced product of dehydrocostus lactone, and alpha-methyl-gamma-butyrolactone, a parent structure of mokko lactone, do not induce HO-1 expression | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme suppression with siRNA abolishes the cytoprotective effect of HO-1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | HO-1 exhibits cytoprotective function, enzyme induction, e.g. by dehydrocostus lactone, causes the nuclear accumulation of the nuclear factor E2-related factor 2, Nrf2, and increases the promoter activity of antioxidant response element, ARE, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 exhibits cytoprotective function, enzyme induction, e.g. by dehydrocostus lactone, causes the nuclear accumulation of the nuclear factor E2-related factor 2, Nrf2, and increases the promoter activity of antioxidant response element, ARE, overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |
inducible heme oxygenase-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |