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Literature summary for 1.14.14.18 extracted from

  • Wen, F.; Brown, K.E.; Britigan, B.E.; Schmidt, W.N.
    Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity (2008), Cell Biol. Toxicol., 24, 175-188.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information HO-1 expression, prooxidative activity, and cytotoxicity are increased after treatment with heme, heavy metals, and peroxides compared to control cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens
-
biliverdin + Fe2+ + CO + A + H2O
-
?
additional information Homo sapiens expression of Hepatitis C virus core protein sensitizes hepatocytes to toxic injury and inhibits the induction of HO-1 in response to stress, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell Hep-G2 cell line C34 Homo sapiens
-
hepatocyte HCV-infected liver biopsies and core protein-expressing hepatocytes show diminished levels of heme oxygenase-1 Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
liver HO-1 is expressed primarily in Kupffer cells, HCV-infected liver biopsies and core protein-expressing hepatocytes show diminished levels of heme oxygenase-1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?
additional information expression of Hepatitis C virus core protein sensitizes hepatocytes to toxic injury and inhibits the induction of HO-1 in response to stress, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Homo sapiens
HO-1
-
Homo sapiens