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Literature summary for 1.14.14.18 extracted from

  • Kroenke, G.; Kadl, A.; Ikonomu, E.; Blueml, S.; Fuernkranz, A.; Sarembock, I.J.; Bochkov, V.N.; Exner, M.; Binder, B.R.; Leitinger, N.
    Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors (2007), Arterioscler. Thromb. Vasc. Biol., 27, 1276-1282.
    View publication on PubMed
Search for more literature for 1.14.14.18

Protein Variants

Protein Variants Comment Organism
additional information a clinically relevant polymorphism within the HO-1 promoter critically influences its transcriptional activation by both PPAR isoforms, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
tin protoporphyrin SnPP, specific HO-1 inhibition abrogating the inhibition of COX-2 expression by Wy-14,643 Homo sapiens
zinc protoporphyrin dose-dependently increases SMC proliferation, induced by either platelet-derived growth factor or 15% fetal bovine serum Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens HO-1 shows vasculoprotective and anti-inflammatory activity, it is ptionally regulated by peroxisome proliferator-activated receptors PPARalpha and PPARgamma in vascular cells, inhibition of HO-1 enzymatic activity reverses PPAR ligand-mediated inhibition of cell proliferation and expression of cyclooxygenase-2 in vascular smooth muscle cells, overview biliverdin + Fe2+ + CO + A + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle cell
-
 Homo sapiens
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vascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?
heme + AH2 + O2 HO-1 shows vasculoprotective and anti-inflammatory activity, it is ptionally regulated by peroxisome proliferator-activated receptors PPARalpha and PPARgamma in vascular cells, inhibition of HO-1 enzymatic activity reverses PPAR ligand-mediated inhibition of cell proliferation and expression of cyclooxygenase-2 in vascular smooth muscle cells, overview Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
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 Homo sapiens
HO-1
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 Homo sapiens