Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | hemin and taurine chloramine, Tau-Cl, raise the transcription of the gene encoding HO-1 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
HO-1 expression analysis by real-time PCR | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zinc(II) deuteroporphyrin IX-2, 4-bisethyleneglycol | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | HO-1 induction in vivo inhibits cytokine production in synovial tissue, while HO-1 inhibition restores it, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
rheumatoid arthritis fibroblast-like synoviocyte | - |
Homo sapiens | - |
synovial tissue | obtained from the knee joints at the time of joint surgery or synovectomy, performed as a normal part of clinical care, from 20 rheumatoid arthritis patients, HO-1 expression analysis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 induction in vivo inhibits cytokine production in synovial tissue, while HO-1 inhibition restores it, overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |