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Literature summary for 1.14.14.18 extracted from

  • Mingone, C.J.; Ahmad, M.; Gupte, S.A.; Chow, J.L.; Wolin, M.S.
    Heme oxygenase-1 induction depletes heme and attenuates pulmonary artery relaxation and guanylate cyclase activation by nitric oxide (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H1244-H1250.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.18

Activating Compound

Activating Compound Comment Organism Structure
Co protoporphyrin IX activates and induces HO-1 Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
CoCl2 activates Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Bos taurus induction of HO-1 leads to a reduction of superoxide and increases levels of spermine-NoNoate, HO-1 is involved in artery vascular relaxation, overview biliverdin + Fe2+ + CO + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus Q5E9F2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery pulmonary Bos taurus
-
endothelial cell
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Bos taurus biliverdin + Fe2+ + CO + A + H2O
-
 ?
heme + AH2 + O2 induction of HO-1 leads to a reduction of superoxide and increases levels of spermine-NoNoate, HO-1 is involved in artery vascular relaxation, overview Bos taurus biliverdin + Fe2+ + CO + A + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Bos taurus
HO-1
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bos taurus