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Literature summary for 1.14.14.18 extracted from
- Heme oxygenase in diabetes-induced oxidative stress in the heart (2003), J. Mol. Cell. Cardiol., 35, 1439-1448.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | treatment of streptozotocin-induced diabetic rats with enzyme inhibitor sn protoporphyrin IX. No significant alterations of the enzyme sytem following one week of diabetes. One month of diabetes caused increased oxidative stress in association with 2.5-fold increase in enzyme activity. Sn protoporphyrin IX treatment reduces the number of 8-hydroxy-2deoxyguanosine-positive cardiomycetes and enzyxme activity. Non-diabetic animals treated with hemin exhibit abnormalities similar to diabetic rats | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Sn protoporphyrin IX | - |
Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
streptozotocin-induced diabetic rats | - |
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