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Literature summary for 1.14.14.18 extracted from
- Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant (2005), J. Biol. Chem., 280, 2797-2806.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| mutant R183E | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R183E | in addition to product biliverdin IXalpha, mutant yields biliverdin IXdelta and traces of biliverdin IXbeta. Crystal structure reveals altered active site hydrogen bonding network | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P09601 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + NADPH + H+ + O2 | - |
Homo sapiens | biliverdin IXalpha + Fe2+ + CO + NADP+ + H2O | wild-type, selective production of biliverdin IXalpha | ? |  |
| heme + NADPH + H+ + O2 | - |
Homo sapiens | biliverdin IXdelta + biliverdin IXalpha + Fe2+ + CO + NADP+ + H2O | mutant R183E, yields about 20% of product biliverdin IXdelta | ? | |
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Release 2023.1 (January 2023)
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