Literature summary for 1.14.14.18 extracted from

Zhou, H.; Migita, C.T.; Sato, M.; Sun, D.; Zhang, X.; Ikeda-Saito, M.; Fujii, H.; Yoshida, T.
Participation of Carboxylate Amino Acid Side Chain in Regiospecific Oxidation of Heme by Heme Oxygenase (2000), J. Am. Chem. Soc., 122, 8311-8312.

No PubMed abstract available

Search for more literature for 1.14.14.18

Protein Variants

Protein Variants	Comment	Organism
R183a	same alpha-regioselectivity as wild-type, only alpha-biliverdin is produced	Rattus norvegicus
R183D	in contrast to wild-type heme oxygenase-1 which converts heme exclusively to alpha-biliverdin, the R183D mutant converts heme to 20% delta-biliverdin in addition to alpha-biliverdin	Rattus norvegicus
R183E	in contrast to wild-type heme oxygenase-1 which converts heme exclusively to alpha-biliverdin, the R183E mutant converts heme to 35% delta-biliverdin and small amounts of beta and gamma-biliverdin in addition to alpha-biliverdin	Rattus norvegicus
R183N	same alpha-regioselectivity as wild-type, only alpha-biliverdin is produced	Rattus norvegicus
R183Q	same alpha-regioselectivity as wild-type, only alpha-biliverdin is produced	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
heme + electron donor + O2	-	Rattus norvegicus	biliverdin + Fe2+ + CO + oxidized eletron donor + H2O	-	?

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Release 2023.1 (January 2023)