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Literature summary for 1.14.14.18 extracted from

  • Kutty, R.K.; Maines, M.D.
    Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria (1987), Biochem. J., 246, 467-474.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.18

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion 77% activity in inner membrane, specifically associated with complex I, NADH: ubiquinone oxidoreductase Bos taurus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + 2 NADH + 2 H+ + 2 O2 Bos taurus NADH-dependent heme degradation system may have a biological role in regulating the concentration of respiratory hemoproteins and the disposition of the aberrant forms of the mitochondrial hemoproteins biliverdin + Fe2+ + CO + 2 NAD+ + H2O
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Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining
heart
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 Bos taurus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00046
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 NADH-dependent heme degradation in heart mitochondria Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + 2 NADH + 2 H+ + 2 O2 NADH-dependent heme degradation system may have a biological role in regulating the concentration of respiratory hemoproteins and the disposition of the aberrant forms of the mitochondrial hemoproteins Bos taurus biliverdin + Fe2+ + CO + 2 NAD+ + H2O
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 ?
heme + electron donor + O2 electron donor NADH Bos taurus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
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heme + electron donor + O2 NADH-dependent heme-degradation activity, 16% of NADH activity with 0.5 mM NADPH Bos taurus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
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heme + electron donor + O2 cytochrome c and myoglobin are not oxidized Bos taurus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
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heme + electron donor + O2 electron donor NADPH Bos taurus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
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 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
90
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 15 min, 95% loss of activity, crude extract Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH 0.5 mM, 16% as effective as NADH Bos taurus