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Literature summary for 1.14.14.18 extracted from

  • Kutty, R.K.; Maines, M.D.
    Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver (1982), J. Biol. Chem., 257, 9944-9952.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CO
-
Rattus norvegicus
KCN
-
Rattus norvegicus
NaN3
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
protoheme
-
Rattus norvegicus
0.01
-
hematoheme
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
mitochondrion liver, 7% of microsomal activity Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus
0.05
-
hematoheme oxidation Rattus norvegicus
0.052
-
protoheme oxidation Rattus norvegicus

Storage Stability

Storage Stability Organism
-30°C, several weeks, no loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hematoheme + NADPH + H+ + O2
-
Rattus norvegicus hematobiliverdin Fe2+ + CO + NAD+ + H2O
-
r
heme + electron donor + O2 electron donor NADH Rattus norvegicus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
?
heme + electron donor + O2 enzyme oxidizes protoheme, hematoheme, hematoheme dimethyl ester, dicysteinyl hematoheme, and heme undecapeptide, conversion of hematoheme to hematobilirubin requires the presence of: NADPH, NADPH-cytochrome c reductase, biliverdin reductase and O2 Rattus norvegicus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
?
heme + electron donor + O2 intact cytochrome c is not oxidized Rattus norvegicus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
?
heme + electron donor + O2 electron donor NADPH Rattus norvegicus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
complete loss of activity Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Rattus norvegicus