Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CO | - |
Rattus norvegicus | |
KCN | - |
Rattus norvegicus | |
NaN3 | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0009 | - |
protoheme | - |
Rattus norvegicus | |
0.01 | - |
hematoheme | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
mitochondrion | liver, 7% of microsomal activity | Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
0.05 | - |
hematoheme oxidation | Rattus norvegicus |
0.052 | - |
protoheme oxidation | Rattus norvegicus |
Storage Stability | Organism |
---|---|
-30°C, several weeks, no loss of activity | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hematoheme + NADPH + H+ + O2 | - |
Rattus norvegicus | hematobiliverdin Fe2+ + CO + NAD+ + H2O | - |
r | |
heme + electron donor + O2 | electron donor NADH | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | enzyme oxidizes protoheme, hematoheme, hematoheme dimethyl ester, dicysteinyl hematoheme, and heme undecapeptide, conversion of hematoheme to hematobilirubin requires the presence of: NADPH, NADPH-cytochrome c reductase, biliverdin reductase and O2 | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | intact cytochrome c is not oxidized | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | electron donor NADPH | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
complete loss of activity | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Rattus norvegicus |