Literature summary for 1.14.14.174 extracted from

Wang, S.; Wang, R.; Liu, T.; Lv, C.; Liang, J.; Kang, C.; Zhou, L.; Guo, J.; Cui, G.; Zhang, Y.; Werck-Reichhart, D.; Guo, L.; Huang, L.
CYP76B74 catalyzes the 3''-hydroxylation of geranylhydroquinone in shikonin biosynthesis (2019), Plant Physiol., 179, 402-414 .

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.023	-	geranylhydroquinone	pH 7.5, 28°C	Arnebia euchroma

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Arnebia euchroma	5783	-
membrane	protein is anchored to the endoplasmic reticulum membrane	Arnebia euchroma	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
geranylhydroquinone + [reduced NADPH-hemoprotein reductase] + O2	Arnebia euchroma	-	3''-hydroxygeranylhydroquinone + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Arnebia euchroma	A0A3Q9R4N5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Arnebia euchroma	-
root	hairy root	Arnebia euchroma	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranylhydroquinone + [reduced NADPH-hemoprotein reductase] + O2	-	Arnebia euchroma	3''-hydroxygeranylhydroquinone + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
CYP76B74	-	Arnebia euchroma

General Information

General Information	Comment	Organism
physiological function	In CYP76B74 RNA interference hairy roots, shikonin derivative accumulation decreases dramatically. CYP76B74 belongs to the CYP76B subfamily and catalyzes the key hydroxylation step in shikonin biosynthesis with high efficiency	Arnebia euchroma

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Release 2023.1 (January 2023)