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Literature summary for 1.14.14.17 extracted from

  • Stevenson, J.; Luu, W.; Kristiana, I.; Brown, A.J.
    Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids (2014), Biochem. J., 461, 435-442.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

General Stability

General Stability Organism
Treatment with 0.1-0.2 mM unsaturated fatty acids such as oleate, but not saturated fatty acids, increases protein levels of the enzyme at the post-translational level Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
squalene + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
squalene mono-oxygenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens