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Literature summary for 1.14.14.17 extracted from

  • Jordan, D.B.
    Squalene oxidase: the elusive flavoenzyme of sterol biosynthesis (1991), Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York, , 865-868.
No PubMed abstract available
Search for more literature for 1.14.14.17

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00043
-
 FAD
-
 Rattus norvegicus
0.00085
-
 1-carba-1-deaza-FAD
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
squalene + electron donor + O2 Rattus norvegicus first oxygenase and last nonsterol reaction of sterol biosynthesis (S)-squalene-2,3-epoxide + oxidized electron donor + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-2,3-epoxy-2,3-dihydrosqualene + 1-carba-1-deaza-FAD + H2O
-
 Rattus norvegicus squalene + 1-carba-1-deaza-FADH2 + O2
-
 r
(3S)-2,3-epoxy-2,3-dihydrosqualene + FAD + H2O
-
 Rattus norvegicus squalene + FADH2 + O2
-
 r
squalene + electron donor + O2 first oxygenase and last nonsterol reaction of sterol biosynthesis Rattus norvegicus (S)-squalene-2,3-epoxide + oxidized electron donor + H2O
-
 ?
squalene + NAD(P)H + O2
-
 Rattus norvegicus (S)-squalene-2,3-epoxide + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
1-Carba-1-deazaFAD can replace FAD as cofactor Rattus norvegicus
FAD flavoprotein Rattus norvegicus
additional information 5-carba-5-deazaFAD cannot replace FAD as cofactor Rattus norvegicus