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Literature summary for 1.14.14.167 extracted from
- Engineering biosynthesis of the anticancer alkaloid noscapine in yeast (2016), Nat. Commun., 7, 12137 .
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | reconstitute of the noscapine gene cluster in Saccharomyces cerevisiae to achieve the microbial production of noscapine and related pathway intermediates | Papaver somniferum |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Saccharomyces cerevisiae. Reconstitution of the noscapine gene cluster in Saccharomyces cerevisiae to achieve the microbial production of noscapine and related pathway intermediates | Papaver somniferum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | Papaver somniferum | the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine | (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Papaver somniferum | I3V6B7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Papaver somniferum | (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine | Papaver somniferum | (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP82X1 | - |
Papaver somniferum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P-450 | heme-thiolate enzyme | Papaver somniferum |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme participates in the biosynthesis of the isoquinoline alkaloid noscapine | Papaver somniferum |
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Release 2023.1 (January 2023)
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