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Literature summary for 1.14.14.161 extracted from

  • Salim, V.; Wiens, B.; Masada-Atsumi, S.; Yu, F.; De Luca, V.
    7-deoxyloganetic acid synthase catalyzes a key 3 step oxidation to form 7-deoxyloganetic acid in Catharanthus roseus iridoid biosynthesis (2014), Phytochemistry, 101, 23-31 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of the gene in Saccharomyces cerevisiae confirms its function as an authentic 7-deoxyloganetic acid synthase that catalyzes the 3 step oxidation of iridodial-nepetalactol to form 7-deoxyloganetic acid Catharanthus roseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 Catharanthus roseus the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
?
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 Catharanthus roseus cv. Little Delicata the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus W8JIS5
-
-
Catharanthus roseus cv. Little Delicata W8JIS5
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction Catharanthus roseus 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
?
(+)-cis,trans-nepetalactol + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids, overall reaction Catharanthus roseus cv. Little Delicata 7-deoxyloganetate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
-
?
(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
(+)-cis,trans-nepetalactol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus cv. Little Delicata 7-deoxyloganetic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
?
7-deoxyloganetic alcohol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus cv. Little Delicata iridotrial + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
?
iridotrial + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
iridotrial + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyses three successive reactions leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus cv. Little Delicata 7-deoxyloganetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
7-deoxyloganetic acid synthase
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Catharanthus roseus
7DLS
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Catharanthus roseus
CYP76A26
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Catharanthus roseus

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450 a cytochrome P-450 (heme thiolate) enzyme Catharanthus roseus

General Information

General Information Comment Organism
malfunction virus-induced gene silencing of 7-deoxyloganetic acid synthase in Catharanthus roseus greatly decreases levels of secologanin and the major monoterpenoid indole alkaloids, catharanthine and vindoline in silenced leaves Catharanthus roseus
metabolism the enzyme catalyses three successive reactions in the seco-iridoid pathway leading to biosynthesis of monoterpenoid indole alkaloids Catharanthus roseus