Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.156 extracted from

  • Hull, A.; Vij, R.; Celenza, J.
    Arabidopsis cytochrome P450s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis (2000), Proc. Natl. Acad. Sci. USA, 97, 2379-2384.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.156

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O81346 CYP79B2; Col-0 ecotype
-
Arabidopsis thaliana Q501D8 CYP79B3; Col-0 ecotype
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 CYP79B2 is specific for L-tryptophan Arabidopsis thaliana (E)-indol-3-ylacetaldoxime + 2 [oxidized NADPH-hemoprotein reductase] + CO2 + 3 H2O
-
 ?
L-tryptophan + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 CYP79B3 is specific for L-tryptophan Arabidopsis thaliana (E)-indol-3-ylacetaldoxime + 2 [oxidized NADPH-hemoprotein reductase] + CO2 + 3 H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP79B2
-
 Arabidopsis thaliana
CYP79B3
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana induction of the CYP79B2 mRNA levels is observed 12.5 h after infection by virulent strain Pseudomonas syringae pv. maculicola up

General Information

General Information Comment Organism
physiological function CYP79B2, when overexpressed in Arabidopsis, confers resistance to toxic analogs of L-tryptophan like 5-methyltryptophan, 5-methylanthranilate, 5-fluoroindole, and 5-fluorotryptophan. In addition, CYP79B2 is expressed in response to bacterial pathogens. CYP79B2 metabolizes L-tryptophan to indole-3-acetaldoxime that can be used for either indole-3-acetic acid or indole glucosinolate biosynthesis Arabidopsis thaliana
physiological function CYP79B3 metabolize L-tryptophan to indole-3-acetaldoxime that can be used for either indole-3-acetic acid or indole glucosinolate biosynthesis Arabidopsis thaliana