Cloned (Comment) | Organism |
---|---|
expression of mutant and wild-type enzymes in Pichia pastoris | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
N136Y | N136Y transformants show a reduced in vitro susceptibility to fluconazole compared to wild-type controls. The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance | Candida albicans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fluconazole | N136Y transformants show a reduced in vitro susceptibility to fluconazole compared to wild-type controls. The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance | Candida albicans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | C8XRD8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERG11 | - |
Candida albicans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Candida albicans |