Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli TOP10F cells and in Pichia pastoris cells | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
K143R | the mutant shows a sustained capacity for producing ergosterol, even in the presence of fluconazole | Candida albicans |
V456I | the mutation leads to an 8fold increase in fluconazole minimal inhibitory concentrations of Pichia pastoris mutants compared to the wild type controls. The mutant shows a sustained capacity for producing ergosterol, even in the presence of fluconazole | Candida albicans |
Y447H | the mutation leads to an 8fold increase in fluconazole minimal inhibitory concentrations of Pichia pastoris mutants compared to the wild type controls. The mutant shows a sustained capacity for producing ergosterol, even in the presence of fluconazole | Candida albicans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fluconazole | - |
Candida albicans |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56000 | - |
x * 56000, SDS-PAGE | Candida albicans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Candida albicans | - |
4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Candida albicans | 4,4-dimethylcholesta-8,14,24-trien-3-ol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 56000, SDS-PAGE | Candida albicans |
Synonyms | Comment | Organism |
---|---|---|
14alpha-demethylase | - |
Candida albicans |
CYP51 | - |
Candida albicans |
Erg11p | - |
Candida albicans |