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Literature summary for 1.14.14.154 extracted from

  • Petushkova, N.; Lisitsa, A.; Pozdnev, V.; Karuzina, I.
    A fluorometric method for determination of catalytic activity of CYP51b1 (sterol 14alpha-demethylase) with coumarin derivatives (2010), Biochemistry (Moscow) Suppl. B, 4, 104-106.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
itraconazole
-
Mycobacterium tuberculosis
ketoconazole
-
Mycobacterium tuberculosis
additional information development of a simple, highly sensitive and accurate method for screening of sterol 14alpha-demethylase inhibitors, overview Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information the enzyme shows a Michaelis-Menten kinetic mechanism, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 Mycobacterium tuberculosis
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lanosterol + [reduced NADPH-hemoprotein reductase] + O2
-
Mycobacterium tuberculosis ?
-
?
additional information CYP51b1 shows activity with coumarin derivatives as substrates, e.g. with 7-ethoxycoumarin, 4-methyl-7-hydroxycoumarin, 4-methyl-7-aminocoumarin, and 7-aminocoumarin-4-acetic acid, that are competitive to lanosterol. In the model system for assay of CYP51b1 activity, a flavin domain of the cytochrome P450BM-3, BMR, from Bacillus megaterium may serve as the electron donor, overview Mycobacterium tuberculosis ?
-
?

Synonyms

Synonyms Comment Organism
CYP51b1
-
Mycobacterium tuberculosis
sterol 14alpha-demethylase
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mycobacterium tuberculosis