Inhibitors | Comment | Organism | Structure |
---|---|---|---|
itraconazole | - |
Mycobacterium tuberculosis | |
ketoconazole | - |
Mycobacterium tuberculosis | |
additional information | development of a simple, highly sensitive and accurate method for screening of sterol 14alpha-demethylase inhibitors, overview | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the enzyme shows a Michaelis-Menten kinetic mechanism, overview | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | Mycobacterium tuberculosis | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mycobacterium tuberculosis | ? | - |
? | |
additional information | CYP51b1 shows activity with coumarin derivatives as substrates, e.g. with 7-ethoxycoumarin, 4-methyl-7-hydroxycoumarin, 4-methyl-7-aminocoumarin, and 7-aminocoumarin-4-acetic acid, that are competitive to lanosterol. In the model system for assay of CYP51b1 activity, a flavin domain of the cytochrome P450BM-3, BMR, from Bacillus megaterium may serve as the electron donor, overview | Mycobacterium tuberculosis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP51b1 | - |
Mycobacterium tuberculosis |
sterol 14alpha-demethylase | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mycobacterium tuberculosis |