Literature summary for 1.14.14.154 extracted from

Maurice, H.; Tuarira, E.; Mwambete, K.
Virtual high screening throughput and design of 14alpha-lanosterol demethylase inhibitors against Mycobacterium tuberculosis (2009), Afr. J. Biotechnol., 8, 3072-3078.

No PubMed abstract available

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Inhibitors

Inhibitors	Comment	Organism	Structure
clomiphene	interacts with heme, is less potent than azoles	Mycobacterium tuberculosis
fluconazole	-	Mycobacterium tuberculosis
glafenine	interacts with heme, shows no potency which may arise from its hydrophilic nature which lower its up-take and capacity to reach the target enzyme	Mycobacterium tuberculosis
ketoconazole	residues lining the ketoconazole pocket include Ala397 and Ala398, Arg389 and Arg393, Asp377, Glu308, Gly390, Ile401, Leu311 and Leu315, Lys312, Phe387, Pro386, Trp382 and Trp384	Mycobacterium tuberculosis
miconazole	-	Mycobacterium tuberculosis
additional information	the aromatic moieties of drugs where aligning to phenylalanine and tyrosine residues that lines the hydrophobic part of the binding pocket which is itself generally hydrophobic	Mycobacterium tuberculosis
N-{2-[4-(acetylamino)phenyl]ethyl}-2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide	interacts with heme	Mycobacterium tuberculosis
rottlerin	interacts with heme	Mycobacterium tuberculosis
SPSM1	interacts with heme	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WPP9	-	-
Mycobacterium tuberculosis H37Rv	P9WPP9	-	-

Synonyms

Synonyms	Comment	Organism
14alpha-lanosterol demethylase	-	Mycobacterium tuberculosis
CYP51	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)