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Literature summary for 1.14.14.154 extracted from

  • Hankins, E.G.; Gillespie, J.R.; Aikenhead, K.; Buckner, F.S.
    Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors (2005), Mol. Biochem. Parasitol., 144, 68-75.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information the lanosterol synthase inhibitor terbinafine and inhibition of squalene epoxidase and lanosterol synthase induce the transcription and translation of the enzyme about 7-12fold, upregulation is mediated through the 3'-untranslated region of the gene Trypanosoma cruzi

Cloned(Commentary)

Cloned (Comment) Organism
expression of His6-tagged enzyme in Escherichia coli strain BL21(DE3), usage of the luciferase expression system Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma cruzi the organism can specifically regulate gene expression, e.g. for the sterol C14-demethylase, in response to derangements in its cellular functions ?
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 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
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Purification (Commentary)

Purification (Comment) Organism
recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the organism can specifically regulate gene expression, e.g. for the sterol C14-demethylase, in response to derangements in its cellular functions Trypanosoma cruzi ?
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 ?

Synonyms

Synonyms Comment Organism
sterol C14-demethylase
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 Trypanosoma cruzi