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Literature summary for 1.14.14.154 extracted from

  • Giner, J.L.; Zhao, H.; Amit, Z.; Kaneshiro, E.S.
    Sterol composition of Pneumocystis jirovecii with blocked 14alpha-demethylase activity (2004), J. Eukaryot. Microbiol., 51, 634-643.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information sterol composition of different species isolated from human lung, two distinct sterol compositional phenotypes occur, one, the wild-type, is characterized by DELTA7 C28- and C24 24-alkylsterols with only low proportions of higher molecular mass components, the other type, a mutant with 14alpha-demethylase deficiency, is dominated by high C31 and C32 24-alkylsterols, especially pneumocysterol, NMR sterol analysis, overview Pneumocystis jirovecii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pneumocystis jirovecii sterol composition of different species isolated from human lung, two distinct sterol compositional phenotypes occur, one, the wild-type, is characterized by DELTA7 C28- and C24 24-alkylsterols with only low proportions of higher molecular mass components, the other type, a mutant with 14alpha-demethylase deficiency, is dominated by high C31 and C32 24-alkylsterols, especially pneumocysterol, NMR sterol analysis, overview ?
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Organism

Organism UniProt Comment Textmining
Pneumocystis jirovecii
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28 different species isolated from human lung
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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wild-type and enzyme-deficient mutant sterol composition, overview Pneumocystis jirovecii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sterol composition of different species isolated from human lung, two distinct sterol compositional phenotypes occur, one, the wild-type, is characterized by DELTA7 C28- and C24 24-alkylsterols with only low proportions of higher molecular mass components, the other type, a mutant with 14alpha-demethylase deficiency, is dominated by high C31 and C32 24-alkylsterols, especially pneumocysterol, NMR sterol analysis, overview Pneumocystis jirovecii ?
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Synonyms

Synonyms Comment Organism
14alpha-demethylase
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Pneumocystis jirovecii
C- I4 demethylase
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Pneumocystis jirovecii