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Literature summary for 1.14.14.154 extracted from
- A functional cytochrome P450 lanosterol 14 alpha-demethylase CYP51 enzyme in the acrosome: transport through the Golgi and synthesis of meiosis-activating sterols (2004), Endocrinology, 145, 1419-1426.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Bos taurus | 5783 | - |
| endoplasmic reticulum | - |
Ovis aries | 5783 | - |
| endoplasmic reticulum | present during all phases of acrosome development | Mus musculus | 5783 | - |
| Golgi apparatus | - |
Bos taurus | 5794 | - |
| Golgi apparatus | - |
Ovis aries | 5794 | - |
| Golgi apparatus | present during all phases of acrosome development, in liver, no detection in trans-Golgi | Mus musculus | 5794 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
x * 50000, SDS-PAGE | Bos taurus |
| 50000 | - |
x * 50000, SDS-PAGE | Ovis aries |
| 53000 | - |
x * 53000, SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Mus musculus | - |
- |
- |
| Ovis aries | - |
ram | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Mus musculus |
| glycoprotein | - |
Bos taurus |
| glycoprotein | - |
Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| germ cell | male | Mus musculus | - |
| germ cell | male | Bos taurus | - |
| germ cell | male | Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Bos taurus | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Ovis aries | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 53000, SDS-PAGE | Mus musculus |
| ? | x * 50000, SDS-PAGE | Bos taurus |
| ? | x * 50000, SDS-PAGE | Ovis aries |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | - |
Mus musculus | |
| cytochrome P450 | - |
Bos taurus | |
| cytochrome P450 | - |
Ovis aries |
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Release 2023.1 (January 2023)
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