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Literature summary for 1.14.14.152 extracted from

  • Seki, H.; Ohyama, K.; Sawai, S.; Mizutani, M.; Ohnishi, T.; Sudo, H.; Akashi, T.; Aoki, T.; Saito, K.; Muranaka, T.
    Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin (2008), Proc. Natl. Acad. Sci. USA, 105, 14204-14209.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Spodoptera frugiperda 9 (Sf9) insect cells Glycyrrhiza uralensis

Organism

Organism UniProt Comment Textmining
Glycyrrhiza uralensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information not detected in leaves and stems Glycyrrhiza uralensis
-
root
-
 Glycyrrhiza uralensis
-
stolon
-
 Glycyrrhiza uralensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
30-hydroxy-beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2
-
 Glycyrrhiza uralensis 11-deoxoglycyrrhetinic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
beta-amyrin + [reduced NADPH-hemoprotein reductase] + O2 two-step oxidation at C-11 with 11alpha-hydroxy-beta-amyrin as intermediate product Glycyrrhiza uralensis 11-oxo-beta-amyrin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP88D6
-
 Glycyrrhiza uralensis

General Information

General Information Comment Organism
metabolism CYP88D6 is a beta-amyrin 11-oxidase in the glycyrrhizin pathway Glycyrrhiza uralensis