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Literature summary for 1.14.14.150 extracted from
- Magnesium and manganese interactively modulate parthenolide accumulation and the antioxidant defense system in the leaves of Tanacetum parthenium (2016), J. Plant Physiol., 202, 10-20 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| COS expression analysis in plants with Mg2+ or Mn2+ feeding or without, overview | Tanacetum parthenium |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for parthenolide biosynthesis in plants, activates the enzyme | Tanacetum parthenium |  |
| Mn2+ | required for parthenolide biosynthesis in plants, activates the enzyme | Tanacetum parthenium | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 | Tanacetum parthenium | - |
(+)-costunolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Tanacetum parthenium | - |
cv. Zardband | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Tanacetum parthenium | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Tanacetum parthenium | (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COS | - |
Tanacetum parthenium |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Tanacetum parthenium |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is one of the key players in the parthenolide biosynthesis, pathway overview | Tanacetum parthenium |
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Release 2023.1 (January 2023)
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