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Literature summary for 1.14.14.14 extracted from

  • Ohlsson, C.; Hammarstedt, A.; Vandenput, L.; Saarinen, N.; Ryberg, H.; Windahl, S.H.; Farman, H.H.; Jansson, J.O.; Moverare-Skrtic, S.; Smith, U.; Zhang, F.P.; Poutanen, M.; Hedjazifar, S.; Sjoegren, K.
    Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice (2017), Am. J. Physiol. Endocrinol. Metab., 313, E450-E462 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P28649
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
metabolism in a male mouse model overexpressing the aromatase enzyme, adipose tissue estradiol levels are increased while circulating sex steroid levels are unaffected. The overexpressing male mice are more insulin sensitive compared with wild-type mice and exhibit increased serum adiponectin levels and upregulated expression of Glut4 and Irs1 in white adipose tissue. The expression of markers of macrophages and immune cell infiltration is markedly decreased in their white adipose tissue Mus musculus