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Literature summary for 1.14.14.139 extracted from

  • Sehayek, E.; Hagey, L.R.; Fung, Y.Y.; Duncan, E.M.; Yu, H.J.; Eggertsen, G.; Bjoerkhem, I.; Hofmann, A.F.; Breslow, J.L.
    Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit (2006), J. Lipid Res., 47, 2020-2027.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene CYP8B1, genotyping of different strains of mice, e.g. C57BL/6J and CASA/Rk mice, and a hybrid of both Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus the enzyme channels bile acid precursors into cholic acid, but is not affected on mRNA and protein levels by increased cholic acid or reduced beta-muricholic acid levels, overview 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6J and CASA/Rk mice, and a hybrid of both
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme channels bile acid precursors into cholic acid, but is not affected on mRNA and protein levels by increased cholic acid or reduced beta-muricholic acid levels, overview Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP8B1
-
 Mus musculus
sterol 12alpha-hydroxylase
-
 Mus musculus