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Literature summary for 1.14.14.127 extracted from

  • Minakuchi, C.; Ishii, F.; Washidu, Y.; Ichikawa, A.; Tanaka, T.; Miura, K.; Shinoda, T.
    Expressional and functional analysis of CYP15A1, a juvenile hormone epoxidase, in the red flour beetle Tribolium castaneum (2015), J. Insect Physiol., 80, 61-70.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Tribolium castaneum

Organism

Organism UniProt Comment Textmining
Tribolium castaneum D6WFY6
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Source Tissue

Source Tissue Comment Organism Textmining
corpus allatum
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 Tribolium castaneum
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additional information level of CYP15A1 mRNA is high in the embryonic stage as well as in the middle of the final larval instar. In the embryonic stage, the transcript level of CYP15A1 starts to increase 30 h after egg laying and peaks 54-60 h after egg laying Tribolium castaneum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
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 Tribolium castaneum ? + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
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 Tribolium castaneum juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O product has (10R)-configuration ?

Synonyms

Synonyms Comment Organism
CYP15A1
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 Tribolium castaneum

General Information

General Information Comment Organism
physiological function RNAi-mediated knockdown of CYP15A1 in the pre-final larval instar does not result in precocious metamorphosis to pupa. The double knockdown of juvenile hormone acid O-methyltransferase and TcCYP15A1 results in pupae and adults with shorter wings Tribolium castaneum