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Literature summary for 1.14.14.121 extracted from
- Protopanaxadiol 6-hydroxylase and its role in regulating the ginsenoside heterogeneity in Panax notoginseng cells (2008), Biotechnol. Bioeng., 100, 933-940.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Phenobarbital | maximal activity with addition of 0.5 mM phenobarbital | Panax notoginseng |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ancymidol | 53.1% residual activity at 0.1 mM | Panax notoginseng | |
| carbon monoxide | an atmosphere of 100% CO completely inhibits enzyme activity in dark. Inhibition by carbon monoxide is partially reversible upon illumination with blue light | Panax notoginseng | |
| cytochrome c | 32.9% residual activity at 0.1 mM | Panax notoginseng | |
| miconazole | 25.7% residual activity at 0.1 mM | Panax notoginseng | |
| additional information | activity is not affected by dimethylsulfoxide at 0.1% (v/v) | Panax notoginseng |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.034 | - |
protopanaxadiol | in 100 mM phosphate buffer (pH 7.6), at 30°C | Panax notoginseng | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Panax notoginseng | very low activity with NADH | ? | - |
? | |
| protopanaxadiol + [reduced NADPH-hemoprotein reductase] + O2 | Panax notoginseng | - |
protopanaxatriol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Panax notoginseng | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | very low activity with NADH | Panax notoginseng | ? | - |
? | |
| protopanaxadiol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Panax notoginseng | protopanaxatriol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| P6H | - |
Panax notoginseng |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
- |
Panax notoginseng |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | - |
Panax notoginseng |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | protopanaxadiol 6-hydroxylase is a key enzyme in regulating Rg-group ginsenoside biosynthesis in Panax notoginseng cells | Panax notoginseng |
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