Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56300 | - |
x * 56300, calculated from amino acid sequence | Aspergillus parasiticus |
56300 | - |
x * 56300, calculated from sequence | Aspergillus parasiticus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | Aspergillus parasiticus | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | Aspergillus parasiticus | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | Aspergillus parasiticus SU1-N3 | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | Aspergillus parasiticus SU1-N3 | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
averantin + [reduced NADPH-hemoprotein reductase] + O2 | Aspergillus parasiticus | - |
5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
averantin + [reduced NADPH-hemoprotein reductase] + O2 | Aspergillus parasiticus SRRC 143 | - |
5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus parasiticus | - |
ATCC 56775 | - |
Aspergillus parasiticus | Q12732 | - |
- |
Aspergillus parasiticus SRRC 143 | - |
ATCC 56775 | - |
Aspergillus parasiticus SU1-N3 | Q12732 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus | (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus | (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus SU1-N3 | (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus SU1-N3 | (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus | (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus | (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus SU1-N3 | (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 | the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin | Aspergillus parasiticus SU1-N3 | (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
averantin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Aspergillus parasiticus | 5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
averantin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Aspergillus parasiticus SRRC 143 | 5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 56300, calculated from amino acid sequence | Aspergillus parasiticus |
? | x * 56300, calculated from sequence | Aspergillus parasiticus |
Synonyms | Comment | Organism |
---|---|---|
avnA | - |
Aspergillus parasiticus |
avnA | gene name, previously named ord-1 | Aspergillus parasiticus |
CYP60A1 | - |
Aspergillus parasiticus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | a cytochrome P-450-type monooxygenase | Aspergillus parasiticus |
General Information | Comment | Organism |
---|---|---|
malfunction | disruption of the avnA gene in the wild type aflatoxigenic Aspergillus parasiticus strain SU1-N3 results in a nonaflatoxigenic mutant which accumulates a bright yellow pigment. Norsolorinic acid and averantin are not converted to aflatoxin by the mutant whereas 5'-hydroxyaverantin, averufanin, averufin, versicolorin A, sterigmatocystin, and O-methylsterigmatocystin are converted to aflatoxins | Aspergillus parasiticus |
metabolism | the enzyme is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway | Aspergillus parasiticus |