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Literature summary for 1.14.14.1 extracted from
- Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase (2010), Am. J. Physiol. Regul. Integr. Comp. Physiol., 299, R325-R333.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? |  |
| additional information | Homo sapiens | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? | |
| additional information | Rattus norvegicus | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
CYP4A11 | - |
| Mus musculus | - |
isozyme Cyp4a12 | - |
| Rattus norvegicus | - |
isozyme CYP4A1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Mus musculus | ? | - |
? | |
| adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Homo sapiens | ? | - |
? | |
| adrenic acid + [reduced NADPH-hemoprotein reductase] + O2 | i.e. all-cis-7,10,13,16-docosatetraenoic acid | Rattus norvegicus | ? | - |
? | |
| arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | ? | - |
? | |
| arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? | |
| arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 20-hydroxyeicosatetraenoic acid + 19-hydroxyeicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | ratio 12:1 | ? | |
| docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| eicosapentaenoic acid + NADPH + H+ + O2 | - |
Homo sapiens | 20-hydroxyeicosapentaenoic acid + NADP+ + H2O | - |
? | |
| eicosapentaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 20-hydroxyeicosapentaenoic acid + 19-hydroxyeicosapentaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | ratio 4:3 | ? | |
| eicosapentaenoic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | 20-hydroxyeicosapentaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| linoleic acid + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | (9Z,12Z)-18-hydroxyoctadeca-9,12-dienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Mus musculus | ? | - |
? | |
| additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Homo sapiens | ? | - |
? | |
| additional information | CYP4A enzymes predominantly function as AA omega-hydroxylases, hydroxy metabolites are roduced by the individual CYP isoforms in a regio- and stereoselective manner. CYP isoforms that do not produce 20-hydroxyeicosatetraenoic acid but function predominantly as AA (omega-1)-hydroxylases include CYP1A1, but also act regioselective | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Mus musculus | ? | - |
? | |
| additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme shows (omega-1)-hydroxylase activity against arachidonic acid, linoleic acid, and especially against eicosapentaenoic acid and docosahexaenoic acid, substrate specificities of isozymes, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AA omega-hydroxylase | - |
Mus musculus |
| AA omega-hydroxylase | - |
Homo sapiens |
| AA omega-hydroxylase | - |
Rattus norvegicus |
| CYP4F2 | - |
Mus musculus |
| CYP4F3A | - |
Mus musculus |
| CYP4F3B | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Mus musculus |
| metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Homo sapiens |
| metabolism | cytochrome P450-dependent metabolism of omega-6 polyunsaturated fatty acids, overview | Rattus norvegicus |
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Release 2023.1 (January 2023)
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