Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.1 extracted from

  • Kranendonk, M.; Marohnic, C.C.; Panda, S.P.; Duarte, M.P.; Oliveira, J.S.; Masters, B.S.; Rueff, J.
    Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley-Bixler syndrome variants of cytochrome P450 oxidoreductase (2008), Arch. Biochem. Biophys., 475, 93-99.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of CYP1A2 with the Y459H and V492E mutant POR alleles in tBTC1A2_POR cell-models Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information CYP1A2, and likely other drug-metabolizing CYPs, are impaired by Antley-Bixler syndrome-related cytochrome P450 reductase mutations as observed in the steroidogenic CYPs Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?
7-methoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CYP1A2
-
Homo sapiens
cytochrome P450 oxidoreductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD FAD totally recovers activities in the BTC1A2_PORV492E membranes, for both 7-ethoxyresorufin and 7-methoxyresorufin, but only partially recovers these activities in the BTC1A2_PORY459H membranes Homo sapiens

General Information

General Information Comment Organism
physiological function Y459H and V492E mutant POR alleles severely hinder the CYP1A2-mediated bioactivation of the three pro-carcinogens 2-aminoanthracene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 2-amino-3-methylimidazo(4,5-f)quinoline Homo sapiens