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Literature summary for 1.14.14.1 extracted from

  • Chan, P.K.; Lu, S.Y.; Liao, J.W.; Wei, C.F.; Tsai, Y.; Ueng, T.H.
    Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol (2006), Food Chem. Toxicol., 44, 2047-2057.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is induced and inhibited by the fungicide bitertanol, application increases the activiy of several cytochrome P450 monooxygenases in liver, kidney, and lung several fold, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
bitertanol 7-ethoxyresorufin O-deethylation is inhibited by the fungicide bitertanol, IC50: 800-900 nM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-ethoxyresorufin + O2 + reduced donor 7-ethoxyresorufin O-deethylation Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
CYP1A1
-
Rattus norvegicus
CYP1B1
-
Rattus norvegicus
CYP2B
-
Rattus norvegicus
CYP3A
-
Rattus norvegicus
cytochrome P450-dependent monooxygenase
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008 0.0009 7-ethoxyresorufin O-deethylation is inhibited by the fungicide bitertanol, IC50: 800-900 nM Rattus norvegicus bitertanol