Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(6-chloro-1H-indazol-1-yl)acetic acid | - |
Homo sapiens | |
2-amino-3-(6-chloro-1H-indazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(1H-indazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(5,6-dichloro-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-1,2-benzoxazol-3-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-1H-indazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-6-cyano-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-6-ethoxy-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-6-ethyl-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-6-methoxy-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-6-methyl-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-chloro-7-methyl-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-cyano-2-methylidene-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(5-methoxy-2-methylidene-1,3-benzoxazol-3(2H)-yl)propanoic acid | - |
Homo sapiens | |
3-(6-bromo-1H-indazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(6-chloro-1H-benzotriazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(6-chloro-1H-indazol-1-yl)-2-hydroxypropanoic acid | - |
Homo sapiens | |
3-(6-chloro-1H-indazol-1-yl)-2-methylpropanoic acid | - |
Homo sapiens | |
3-(6-chloro-1H-indazol-1-yl)butanoic acid | - |
Homo sapiens | |
3-(6-chloro-1H-indazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(6-chloro-1H-indol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(6-chloro-3-methyl-1H-indazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-(6-chloro-3-oxo-3,4-dihydro-2H-1-benzopyran-4-yl)propanoic acid | - |
Homo sapiens | |
3-(6-methyl-1H-indazol-1-yl)propanoic acid | - |
Homo sapiens | |
3-[2-methylidene-5-(trifluoromethyl)-1,3-benzoxazol-3(2H)-yl]propanoic acid | - |
Homo sapiens | |
3-[5-chloro-2-oxo-6-(propan-2-yl)-1,3-benzoxazol-3(2H)-yl]propanoic acid | - |
Homo sapiens | |
3-[5-chloro-2-oxo-6-(trifluoromethyl)-1,3-benzoxazol-3(2H)-yl]propanoic acid | - |
Homo sapiens | |
3-[5-chloro-2-oxo-6-[(propan-2-yl)oxy]-1,3-benzoxazol-3(2H)-yl]propanoic acid | - |
Homo sapiens | |
3-[5-chloro-6-(cyclopropyloxy)-2-oxo-1,3-benzoxazol-3(2H)-yl]propanoic acid | - |
Homo sapiens | |
4-(6-chloro-1H-indazol-1-yl)butanoic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + NADPH + H+ + O2 | Homo sapiens | the enzyme is involved in tryptophan catabolism | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15229 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + NADPH + H+ + O2 | - |
Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
L-kynurenine + NADPH + H+ + O2 | the enzyme is involved in tryptophan catabolism | Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | flavoenzyme | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000032 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[5-chloro-6-(cyclopropyloxy)-2-oxo-1,3-benzoxazol-3(2H)-yl]propanoic acid | |
0.000005 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-6-ethoxy-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.0000063 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5,6-dichloro-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.00001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-6-ethyl-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.000013 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.000013 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-6-methyl-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.000013 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-6-methoxy-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.000025 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-1,2-benzoxazol-3-yl)propanoic acid | |
0.0000398 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-bromo-1H-indazol-1-yl)propanoic acid | |
0.0000398 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[5-chloro-2-oxo-6-(trifluoromethyl)-1,3-benzoxazol-3(2H)-yl]propanoic acid | |
0.00005 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-1H-indazol-1-yl)propanoic acid | |
0.000063 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-7-methyl-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.000079 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-3-oxo-3,4-dihydro-2H-1-benzopyran-4-yl)propanoic acid | |
0.000079 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[5-chloro-2-oxo-6-[(propan-2-yl)oxy]-1,3-benzoxazol-3(2H)-yl]propanoic acid | |
0.0001 | - |
pH and temperature not specified in the publication | Homo sapiens | (6-chloro-1H-indazol-1-yl)acetic acid | |
0.0001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-6-cyano-2-oxo-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.0001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[5-chloro-2-oxo-6-(propan-2-yl)-1,3-benzoxazol-3(2H)-yl]propanoic acid | |
0.00013 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-1H-indol-1-yl)propanoic acid | |
0.0005 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-1H-benzotriazol-1-yl)propanoic acid | |
0.0006 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-1H-indazol-1-yl)-2-hydroxypropanoic acid | |
0.00063 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-cyano-2-methylidene-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-chloro-1H-indazol-1-yl)propanoic acid | |
0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(5-methoxy-2-methylidene-1,3-benzoxazol-3(2H)-yl)propanoic acid | |
0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-3-methyl-1H-indazol-1-yl)propanoic acid | |
0.0025 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-1H-indazol-1-yl)-2-methylpropanoic acid | |
0.0025 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-amino-3-(6-chloro-1H-indazol-1-yl)propanoic acid | |
0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-(6-chloro-1H-indazol-1-yl)butanoic acid | |
0.0032 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-methyl-1H-indazol-1-yl)propanoic acid | |
0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(6-chloro-1H-indazol-1-yl)butanoic acid | |
0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-[2-methylidene-5-(trifluoromethyl)-1,3-benzoxazol-3(2H)-yl]propanoic acid | |
0.0063 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(1H-indazol-1-yl)propanoic acid |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in tryptophan catabolism | Homo sapiens |