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Literature summary for 1.14.13.9 extracted from

  • Ragazzi, E.; Costa, C.V.; Comai, S.; Bertazzo, A.; Caparrotta, L.; Allegri, G.
    Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits (2006), Life Sci., 78, 785-794.
    View publication on PubMed
Search for more literature for 1.14.13.9

Inhibitors

Inhibitors Comment Organism Structure
additional information the specific enzyme activity is not affected by cloricromene in vitro and in vivo in liver and kidney Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Oryctolagus cuniculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
kynurenine + NADPH + O2 Oryctolagus cuniculus the enzyme is involved in the kynurenine pathway of tryptophan metabolsim, overview 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 male, 4-month-old diabetic/hyperlipidemic New Zealand White rabbits
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Oryctolagus cuniculus
-
liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0004
-
 activity in kidney Oryctolagus cuniculus
0.001
-
 activity in liver Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynurenine + NADPH + O2
-
 Oryctolagus cuniculus 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?
kynurenine + NADPH + O2 the enzyme is involved in the kynurenine pathway of tryptophan metabolsim, overview Oryctolagus cuniculus 3-hydroxy-kynurenine + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Oryctolagus cuniculus