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Literature summary for 1.14.13.9 extracted from

  • Drysdale, M.J.; Hind, S.L.; Jansen, M.; Reinhard, J.F.Jr
    Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: Potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents (2000), J. Med. Chem., 43, 123-127.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition by various 2-amino-4-aryl-4-oxobut-2-enoic acids and esters at 10 micromolar; inhibition by various 4-aryl-2-hyroxy-4-oxobut-2-enoic acids and esters at 10 micromolar Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
Homo sapiens
-